Sunday, June 19, 2016

Route of vaccination determines level of protection against coronaviruses (SARS, MERS)

The coronaviruses (CoV) such as Middle East respiratory syndrome (MERS)-CoV and severe acute respiratory syndrome (SARS)-CoV "have crossed species to cause severe human respiratory disease."

New study in Immunity tested vaccine design based on Venezuelan equine encephalitis replicons (VRP) encoding a SARS-CoV CD4+ T cell epitope derived from nucleocapsid (N) protein of SARS-CoV (N353). VRPs are non-replicating viral vectors that preferentially "infect human and mouse dendritic cells and serve as self-adjuvants". The N protein is "conserved among different coronaviruses" and unlike highly variable S protein, it could induce cross-protection at T cell level.

I reviewed this paper to emphasize that "route of vaccination" that induces antigen-specific T cells residing at the port of [pathogen] entry is crucial in vaccine effectiveness.   

David Usharauli

No comments:

Post a Comment