Saturday, June 24, 2017

α-synuclein in Parkinson’s disease could be a target of autoimmune attack

Parkinson's disease is a neurodegenerative movement disorder characterized by the death of dopaminergic neurons and accumulation of  intraneuronal aggregates known as Lewy bodies that are composed of α -synuclein (α -syn). 

New study in Nature suggests that T cells recognizing epitopes from α -synuclein could contribute to Parkinson's diseases pathogenesis, especially on DRB1* 15:01 and DRB5* 01:01 backgrounds.

Of course, in humans it is quite hard to prove any causation directly.

posted by David Usharauli