New study @nature from Japanese scientists (Konda, Atarashi, & others) identified #consortium (a nice clickbait for granting/funding agencies) of 11 microbial species from human faecal #microbiota that increase #IFN-gamma+ #CD8 T cells protective against #infection and #tumors.— David Usharauli (@3DiMMUNE) January 24, 2019
2. Even these 11 strain #consortium could be further narrowed down into two groups of 7 #Bacteroidales and 4 non-Bacteroidales species. But effect on CD8 T cells was mostly lost when they were separated. pic.twitter.com/UOzqWNFJQz— David Usharauli (@3DiMMUNE) January 24, 2019
3. Significantly, effect of consortium on T cells were #biologically relevant as it improved #protection against #pathogen challenge. pic.twitter.com/Wotr8HJ4p5— David Usharauli (@3DiMMUNE) January 24, 2019
5. Though such #tumor protective effect of this consortium alone was less obvious in SPF mice (regular lab mouse). But even in SPF mice combination of #consortium + #checkpoint inhibitors show a #synergy. pic.twitter.com/H9Iyv13E0o— David Usharauli (@3DiMMUNE) January 24, 2019
scientifically speaking it is not very important paper. It lacks mechanisms & granularity typical for great papers.On the other hand,several authors including senior author are part of microbiota biotech company @VedantaBio and there these data might be sufficient for investment.— David Usharauli (@3DiMMUNE) January 24, 2019
