β-synuclein specific CD4+ T cells invade #brain grey matter and cause array of MS-like #symptoms in a rat model of human #MultipleSclerosis. Interestingly, the most useful distilled data points were in suppl materials. #immunology #autoimmunedisease https://t.co/NbIt5ijxuR— David Usharauli (@3DiMMUNE) March 5, 2019
highlights from paper— David Usharauli (@3DiMMUNE) March 5, 2019
2. Such exclusive invasion of brain grey matter were primarily correlated by pattern of #antigen (β-synuclein) expression. #autoimmunedisease #immunology pic.twitter.com/1r9ROgtTDV
Some thoughts: here the authors have used either WT or transgenic rat expressing β-synuclein-specific T cells. Diseases were induced either following direct immunization of transgenic rats or adoptive transfer of activated β-#synuclein-specific T cell blasts. #immunology— David Usharauli (@3DiMMUNE) March 5, 2019
Con't: immunologists have fairly good idea about processes that represent immune response but at presently it is still unknown how immune response is #initiated naturally or how it is #stopped. This is Achilles heels of current experimental models in #immunology.— David Usharauli (@3DiMMUNE) March 5, 2019
