Thursday, April 14, 2016

T cell compatible cancer chemotherapy synergizes with cancer adjuvant vaccine

Nowadays it is well acknowledged that optimal cancer treatment would require multi-pronged approach, for example, combining cancer chemotherapy with cancer antigen-specific vaccine to boost tumor-specific T cell response. However, such combination is not always feasible since (a) both tumor and activated T cells are highly proliferative cell types and (b) vast majority of chemotherapy drugs target cellular replication machinery. Basically, it is matter of trial and error to find T cell compatible chemotherapy drugs.


Most cervical cancers in humans are induced by human papillomavirus type 16 (HPV16). Initially, the authors showed that CarboTaxol synergized with HPV16-SLP vaccination in HPV16-positive TC-1 tumor-bearing mouse model.



Next, the authors noticed that CarboTaxol [and vaccine too] reduced level of CD11bhighGr1high myeloid [suppressor] population within tumor tissue.



Similar depletion of myeloid population was observed in blood samples of cervical cancer patients undergoing CarboTaxol therapy.


In fact, CarboTaxol treatment cycles significantly improved T cells proliferation in response to minor [bacterial recall antigen mixture, MRM)] and major HLA antigens [MLR].



Finally, combining CarboTaxol treatment with HPV16-SLP vaccination improved T cell stimulation in response to HPV16 antigens E6/E7.



In summary, this study indicates that CarboTaxol chemotherapy augments, rather than inhibits, tumor-specific T cell priming in response to HPV16-SLP vaccination.

David Usharauli


9 comments:

  1. Hello, everyone! I,m here to explore blogs and forum about the wonderful and most safe cure for (Herpes Virus).I was positive to the deadly virus called herpes and i lost hope because i was out casted and rejected even by my closet friends.i searched on-line to know and enquirer about cure for Herpes and i read someone testimony on how he was cured from Herpes so i decided to contact the same herbalist because i know that nature has the power to heal everything.i contacted him to know how he can help me and he told me never to worry that he will heal me with the natural herbs from God!after 2 days of contacting him, he told me that the cure has been ready and he sent it to me via DHL and it got to me after 3 days!i used the med as he instructed me (MORNING and EVENING) and i was cured!its really like a dream but i am so happy!thats the reason i decided to also add more comment of Him so that more can be saved just like me!and if you need his help, you can email him on drucheherbalmedicine@gmail.com  , or WhatsApp +2348050777527  I,m neme amber and you can get in touch with me via drucheherbalmedicine@gmail.com  ..Contact him for help at Herpes virus HIV/AIDS CANCER COPD BRAIN TUMOR All kind of virus and disease //...

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    Replies
    1. Its a miracle that I am alive today. I encounter HERPES SIMPLEX VIRUS (HSV1/2) for good four (4) years, six (6) months and twelve (12) day with my calculations, before I meet the great Dr. Emmanuel. I am DEBORAH from Fresno California, united state of America and I was affected with herpes virus.Herpes is a viral infection cause by the Herpes simplex virus, marked by painful, watery blister in the skin or mucous membrane or on the genitals. This was what I suffered for good four years. I have visited CVS Pharmacy in Fresno for treatment but no improvement. I meet Dr.Emmanuel online while I was searching for herpes cure I read a testimony about his work. I give a try that now becomes a testimony in my life. I contacted Dr.Emmanuel WhatsApp  +2348140073965 or E-mail: nativehealthclinic@gmail.com  

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    2. I'm so exited to share my testimonies about the Good Work of Dr. Udebhu who get me cured from herpes simplex virus (HSV1&2) with his herbs, I never thought that I will live on earth before the year runs out. I have been suffering from herpes, I had spent a lot of money going from one Hospital to another looking for way to get rid of this disease, the hospital have been my home everyday residence. Constant checks up have been my hobby not until this faithful day, I was searching
       through the internet, I saw a testimony on how Dr.Udebhu helped someone in curing his herpes disease using his healing
       Herbs, quickly I copied his email just to give him a test I spoke to him, he told me that he is going to provide the herbal cure to me, which he
      did, after i receive his herbs and i take it as instructed i was cure permanently from herpes my herpes disease was gone. so I decided to share my testimony, that nothing is impossible with God, God use a man to healed me. No matter what you are passing through, no matter how deadly the sickness is and no matter what the situation is God that did mine is still going to do yours, people suffering from herpes, brain tumor, kidney disease, pcos, AIDS, ALS,copd, asthma, athritis,herpes, Cancer,Hpv, any kind of disease, you can rich him now via ? Gmail address: drudebhuherbalhome@gmail.com or whatsapp +2349051254152

      Delete
    3. what a great Joy in my heart i never believe there is a cure for Herpes because my doctor tested me Herpes positive and she told me there is no cure, i’m very happy today that i’m having a free life without this disease, i can remember some years ago when i was crying all through the night and day that i can’t get cured from this sickness, i found this herbal man email on internet when i was doing research on cure for Herpes i contacted DR.Ehiaguna to found out if i can get help from this disease, i was so surprise when he told me that he have the cure to it and he sent me the herbal medicine i was so happy when i get someone giving me hope that he can cured me i took the herbal for just 14 days, when i went for test after taking the herbal i found out that i am cured, i was so happy and surprise, i want to use this opportunity to inform you that there is cured to Herpes you can also contact him for his help as soon as possible so that you can get rid of yours once and for all you can reach him through his email via drehiaguna@gmail.com or whatsApp him on +2348073908953 You can also contact him on any disease in this he have all the herbal cure to it..

      Delete
  2. HELLO EVERYONE.. FEW MUNINETS TO REDY THIS INFOR ON HERPES CURE 2018..
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    ReplyDelete
  3. Its a miracle that I am alive today. I encounter HERPES SIMPLEX VIRUS (HSV1/2) for good four (4) years, six (6) months and twelve (12) day with my calculations, before I meet the great Dr. Emmanuel. I am DEBORAH from Fresno California, united state of America and I was affected with herpes virus.Herpes is a viral infection cause by the Herpes simplex virus, marked by painful, watery blister in the skin or mucous membrane or on the genitals. This was what I suffered for good four years. I have visited CVS Pharmacy in Fresno for treatment but no improvement. I meet Dr.Emmanuel online while I was searching for herpes cure I read a testimony about his work. I give a try that now becomes a testimony in my life. I contacted Dr.Emmanuel WhatsApp  +2348140073965 or E-mail: nativehealthclinic@gmail.com  

    ReplyDelete
  4. I'm so exited to share my testimonies about the Good Work of Dr. Udebhu who get me cured from herpes simplex virus (HSV1&2) with his herbs, I never thought that I will live on earth before the year runs out. I have been suffering from herpes, I had spent a lot of money going from one Hospital to another looking for way to get rid of this disease, the hospital have been my home everyday residence. Constant checks up have been my hobby not until this faithful day, I was searching
     through the internet, I saw a testimony on how Dr.Udebhu helped someone in curing his herpes disease using his healing
     Herbs, quickly I copied his email just to give him a test I spoke to him, he told me that he is going to provide the herbal cure to me, which he
    did, after i receive his herbs and i take it as instructed i was cure permanently from herpes my herpes disease was gone. so I decided to share my testimony, that nothing is impossible with God, God use a man to healed me. No matter what you are passing through, no matter how deadly the sickness is and no matter what the situation is God that did mine is still going to do yours, people suffering from herpes, brain tumor, kidney disease, pcos, AIDS, ALS,copd, asthma, athritis,herpes, Cancer,Hpv, any kind of disease, you can rich him now via ? Gmail address: drudebhuherbalhome@gmail.com or whatsapp +2349051254152

    ReplyDelete
  5. what a great Joy in my heart i never believe there is a cure for Herpes because my doctor tested me Herpes positive and she told me there is no cure, i’m very happy today that i’m having a free life without this disease, i can remember some years ago when i was crying all through the night and day that i can’t get cured from this sickness, i found this herbal man email on internet when i was doing research on cure for Herpes i contacted DR.Ehiaguna to found out if i can get help from this disease, i was so surprise when he told me that he have the cure to it and he sent me the herbal medicine i was so happy when i get someone giving me hope that he can cured me i took the herbal for just 14 days, when i went for test after taking the herbal i found out that i am cured, i was so happy and surprise, i want to use this opportunity to inform you that there is cured to Herpes you can also contact him for his help as soon as possible so that you can get rid of yours once and for all you can reach him through his email via drehiaguna@gmail.com or whatsApp him on +2348073908953 You can also contact him on any disease in this he have all the herbal cure to it..

    ReplyDelete
  6. God bless Dr ODUWA for his marvelous work in my life, I was diagnosed of HPV SIMPLEX VIRUS since 2010 and I was taking my medications, I wasn't satisfied i needed to get the HIV out of my system, I searched about some possible cure for HPV i saw a comment about Dr ODUWA, how he cured HPV with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine within 3days. I took the medicine as prescribed by him and 2weeks later i was cured from HPV contact him via email dr.oduwaspellhome@gmail.com. once again thanks to you DR . ODUWA cure the flowing virus, contact his email or add him on whatsapp +2348070685053)

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