Sunday, November 8, 2015

Genentech's Trojan horse destroys cocooned Staphylococcus aureus

Genentech did it again. It is truly amazing that since its inception in late 70s, Genentech, a bona fide biotech company, keeps its original spirit alive and encourages and supports R&D scientists to conduct and produce quality research befitting publication in top journals. I think in this regard Genentech does not have a single peer in whole of biotech industry.  


First, they showed that unlike freely floating extracellular S. aureus, intracellularly entrenched, hard to reach S. aureus are of clinical relevance


Indeed, in vitro experiments confirmed that intracellular S. aureus are resistance to conventional antibiotic application.


To overcome this resistance, Genentech's team designed antibody-antibiotic complex, called rifalogue, that was made of anti-S. aureus antibody and antibiotic rifampicin complex. The authors first showed that in vitro once rifalogue attached to S. aureus is internalized by cells rifampicin is released from complexes [in endosomes] and destroys S. aureus.


Finally, the authors confirmed effectiveness of this strategy against S. aureus in in vivo experiments as well.


In summary, these results (re)-opens the door for immunotherapy against infectious agents.

I would admit that for me data seems extremely clear-cut. This is a little bit concerning. I want to see these results confirmed in other labs. Another puzzling point is its mechanism of action. The model proposes that rifalogue works by engaging S. aureus with its Fab part and mammalian cells by its FcR. This suggests that rifalogue can't access or destroy S. aureus already cocooned within cells, but it could prevent freely floating S. aureus becoming intracellular. But regular rifampicin is capable of destroying freely floating S. aureus too. So this is a paradox for me [because results showed that rifalogue was still highly effective, even after delay of 24h, against "potentially" intracellular S. aureus]. 

David Usharauli

32 comments:

  1. I was once a victim of staph. Staph infection is deadly, and should be get rid as soon as possible, it usually begins as a small area of tenderness, swelling and redness. Herbal Medicine is the best for this infection, I have finally been cure of staph. If you have staph, don't be discourage, stop using Western medicine and embrace herbal product or contact directly Jack for help. (drjack430@gmail.com)

    ReplyDelete
    Replies
    1. MY NAME IS SOPHIE.

      dr george,herbal treatment is the best to shrink fibroid naturally.

      Four months ago, I was scheduled an operation to remove a fairly large uterine fibroid (approx. 7 cm), which had caused me a great deal of pelvic pain and pressure on my bladder. My doctor insisted that there was no other choice but to go under the knife and I had reluctantly agreed (after trying several medications to decrease the size of the fibroid to no avail). It was approx. 2 months prior to the surgery when my husband comes across dr george herbal remedies which my husband found and ordered for me online. With the help of my loving husband, I followed the step and procedure on how i should be taking it. and 2 weeks later I was scheduled for an ultrasound check: it was shocking. The fibroid had completely gone, I had consulted my doctor and cancelled the surgery and with your dedicated counseling guidance I managed to completely treat the fibroid from my uterus, along with the pain and anxiety that this condition had inflicted on me. Thank you so much for your kind help,any body with similar problem should contact him on his email address drgeorge2580@gmail.com his a good man.

      -- Sophie Brewster

      Delete
  2. I give All thanks to Dr Alegbe,I got the cure for staph from Dr alegbe,i got his contact from the internet,and i mailed him and promise him that if his medication can cure me completely,I will tell the world about him,he gave me his medication which i used from two weeks,and now am cure from the problem of staph,he also has the cure to Weak Erection in men
    Diabetes
    Pile and Epilepsy so any body with such problem can contact him on alegbe3@gmail.com

    ReplyDelete
  3. I give all thanks to dr leonard for helping me to cure STAPH problem which i have been going through for the past 10years, i really tried many prescribed medicine but could not work for me till i was privileged to meet this great doctor who helped me with a positive solution and you can also be cured if you are suffering of STAPH by contacting Dr Leonard at drleonard288@gmail.com.

    ReplyDelete
  4. Do you know that there is a great Herbal doctor who can cure any disease? Like Cancer, HIV, HPV, syphilis, diabetes, herpes, anthrax, madness, low spam count, pregnancy And also bring back your Lover E.t.c. Well my main reason why i am writing this right now is to inform the whole world about the great deeds, DR. john did for me. My name is Ruiz paul, I was diagnosed of HIV in the year 2012 ever since then I was taking my medications, until I met the great spell caster, though I never believed in spell. I saw many testimonies on how he cured deadly diseases. I contacted him through his phone number. I called him, he asked me to send him my email, which I did. He told me that his god’s required some items in which he will use in casting a curing spell on me. I don’t know where to find the items he required. He told me that the only alternative is for me to send him the money, and then he can help me to get the items and herbs for my treatment. I promised myself to do anything to get cured. I sent him the money. He bought the items and casted a curing spell on me and also sent me a herbal potion, I used it as He instructed. 7 days later he asked me to go for check up, when I did the check up I was tested HIV Negative. I am so happy, I can not stop thanking Him, if you passing through hardship and you need a way out, kindly contact his mobile number+2348107345943

    ReplyDelete

  5. Finally a mother.
    For 8 years my husband and i tried ceaselessly to conceive to no avail. The gynecologist told us that the Fibroid is causing difficulties and he recommended a surgery. I love my life so much and i did't want to undergo any surgery because i was told it's too painful and also there are 80% of it growing back. I was discussing this with a close colleague who told me how Dr Aleta helped her cousin cure fibroid. I contacted her and she was so amazing with encouragements and finally sent me a very effective medicine that changed my life for good. It has been four years now and i am still very fine and i have son i call my own naturally. You too can reach her too on aletedwin@gmail.com for her medicine.

    ReplyDelete
  6. ALL THANKS TO DR WILLIAMS.
    For 8 years my husband and i tried ceaselessly to conceive to no avail. The gynecologist told us that the Fibroid is causing difficulties and he recommended a surgery. I love my life so much and i did't want to undergo any surgery because i was told it's too painful and also there are 80% chances of it growing back. I was discussing this with a close colleague who told me how Dr williams helped her cousin cure fibroid. I contacted him and he was so amazing with encouragements and finally sent me a very effective medicine that changed my life for good. It has been four years now and i am still very fine and i have son i call my own naturally. You too can reach him too on drwilliams098765@gmail.com for his medicine

    ReplyDelete
  7. ALL THANKS TO DR WILLIAMS FOR GETTING MY WIFE OUT OF FIBROID WITH HIS HERB One of the greatest moments in this world is when you see your own wife put to bed, this awesome moments makes you a man and not just a man a real man. My wife suffered from Fibroid which made her unable to get pregnant and give us a child for almost 18 years with multiple surgeries done and none seemed to help the situation. I almost gave up but due to the love i had for her because i married her a virgin i had to find a way to help her. I told a member of my church who recommended Dr. williams to me, i contacted him and he sent me a medicine and this medicine shrinked it naturally in a weeks it was like magic but it’s science. I am happy writing this because he delivered a baby girl. Do not loose hope too soon contact him on drwilliams098765@gmail.com and i am confident she will help you too.

    ReplyDelete
    Replies

    1. why are you copying someone's testimony? stop editing their testimonies, it's embarrassing stop it.

      Delete
  8. ALL THANKS TO DR BABALORIXA FOR THE GREAT DEED HE HAVE DONE FOR MY DAUGHTER?
    My daughter suffered from a terrible tinnitus for more than 15years which started after she turned 5 we all thought it will end but got even worse as days went by. We tried all several treatments and therapy prescribed by various doctors we met but to no avail, she lost total concentration and screamed most times. She usually tells me she hears hissing and ringing noises. This were steady noise that disrupted her entire life, even at night she screams even more because the sounds become louder because everywhere is quiet and she slept less because of this.It was during a casual conversation with a friend that i learned about Dr babalorixa herbal medicine I was able to contact him on his email address. and give him all the necessary information that he needed,few day later he sent me the herbal portion and his medicine was able to restore her back to normal and she is very okay now without any side effects whatsoever. If you have Tinnitus, do not hesitate to contact him on babalorixaharbalhome@gmail.com for advice and for his product. I hope this also helps someone out there

    ReplyDelete
  9. ALL THANKS TO DR WILLIAMS.
    For 8 years my husband and i tried ceaselessly to conceive to no avail. The gynecologist told us that the Fibroid is causing difficulties and he recommended a surgery. I love my life so much and i did't want to undergo any surgery because i was told it's too painful and also there are 80% chances of it growing back. I was discussing this with a close colleague who told me how Dr williams helped her cousin cure fibroid and fallopian tube blockage. I contacted him and he was so amazing with encouragements and finally sent me a very effective medicine that changed my life for good. It has been four years now and i am still very fine and i have son i call my own naturally. You too can reach him too on drwilliams098765@gmail.com for his medicine

    ReplyDelete
    Replies

    1. why are you copying someone's testimony? stop editing their testimonies, it's embarrassing stop it.

      Delete
  10. Hello!! I’m indeed very happy for the great help that Dr. okorom rendered to me, I was a herpes patient my husband also was a herpes patient, we saw a blog whereby Dr. okorom cured herpes, we (Me and My Husband) decided to contact him which we did, he asked us to buy some items, unfailingly we sent him the money he will need in buying the items required, He castes the spell and asked us to go for check-up after three days of casting the spell, Luckily for us we were tested herpes negative, now I believe all these Testimonies about him on the internet, he is truly a great man, if you want to discuss with me on how he cured us, kindly email me on deanfneilsarah@gmail.com or you can contact the great Herbalist and a spell caster on dr.okoromspellhome@live.com or you can call him via his mobile phone number on +2348158168556

    ReplyDelete
  11. I got married to my lovely husband for the past 7 years without conceiving and fibroid was the issue, i took different prescribed medication but could not cure it but my husband was so confident in me and kept encouraging me that one day someone would call me mother, we did not rest searching for solution from different Doctors all they could say was surgery and i was afraid of that then a friend in my office introduced me to Dr. Davismartin who sent his product to me which i took and it really worked perfectly, and my Dr. confirm me pregnant after 2 months of taken his product. i gave birth to a BABY GIRL February this year and i will named her TESTIMONY. contact him also at drdavismartin62@gmail.com.

    ReplyDelete
    Replies

    1. why are you copying someone's testimony? stop editing their testimonies, it's embarrassing stop it.

      Delete
  12. This is a great write up, I was also a victim, having uterine fibroid for many years. The size of my fibroid was very large as a grapefruit in my womb, trying to conceive was so hard. My difficulty was not only getting pregnant, but keeping the pregnancy. I occasionally had reoccurring bouts with dysfunctional uterine bleeding due to fibroid tumors. I even came close to having a hysterectomy, but due to future/possible complications, I refused. I learned about some herbs mixture prepared by Dr.Davismartin and that was my breakthrough to a long standing problem. I already gave birth to a bouncing baby boy, very healthy, happy, and bright. I forgot to mention that my non-existent sex drive returned within just a few weeks of starting the herbs, this was a pleasant surprise. If interested and ready to give a try contact him via drdavismartin62@gmail.com

    ReplyDelete
    Replies
    1. why are you copying my testimony? That's my testimony, not yours. So stop editing my testimony, I don't even know the Doctor you mentioned. I have also seen a lot of testimonies which you have edited it's embarrassing stop it.

      Delete
  13. I am 40 years old and I have fibroids, 11 fibroids. No

    kids yet, trying. I don't have any pain but I bleed

    extremely heavy. After suffering for about 5 years, I went

    and had Acessa procedure done in March, 2016, now it is

    2017. I am still bleeding exactly the same, heavy, and my

    fibroids didn't shrink. I am very stressed, if I knew I

    should have not done it. I am not saying Acessa procedure

    is bad, but it didn't help me a bit.but i want to say a

    big thanks to dr buba who helped me get cured i got his

    mail from the internet as i was lookinf for blogs where

    herbs can cure mei was not so sure about him but i

    contacted him and gave my details to him and i did as he

    asked me and today i am cured after i used his herbal drug

    for just a week you should do same too contact

    dr.bubaspellhome@gmail.com or call +2348087937686 thanks

    all

    ReplyDelete

  14. It was January 2014. I was having major pain in my abdomen for months, I was to start a new job and was very excited about it. My job required me to work for 8hours of 24hours per day. On my second week of work, I began my cycle. I could tell right away this period was different, it started out really bad. One week went by and it kept getting worse and more heavy.
    In March, I received a diagnosis and was scheduled for surgery at the end of that month. On April 3, I had a myomectomy, removal of my Fibroids, That was a very difficult surgery which left me in excruciating pain, I developed complications with my breathing after surgery. After a year there was nothing to show as the fibroid kept growing back. But thankfully I’ve heard of Dr. Leonard's Herbal Medicine and decided to give it a trier to my surprise, I started to experience some changes within 3weeks of taking his medicine as my menstrual cycle was still a bit heavy but the color was lighter than usual, clots were moderate. I met with my doctor last week. We discussed the results from my fibroids and he didn't find any. You can contact Doc. at drleonard288@gmail.com.

    ReplyDelete
  15. I GIVE THANKS TO DR WILLIAMS FOR GIVING ME LIFE.
    He helped me with a fast cure to fibroid,and the size of it was .7cm, Then I started taking the medication for only one month, and now am completely cured from it. I was able to make it without any surgery, now I can live like every normal human and I can eat any food of my choice If you need such help, contact him via mail on drwilliams098765@gmail.com for advice,i hope this also help some one out there.

    ReplyDelete
  16. ALL THANKS TO DR WILLIAMS WITH HIS HERBAL PORTION I WAS COMPLETELY CURED FROM FIBROID
    I can’t believe this. A great testimony that i must share to all fibroid patient in the world. i never believed that their could be any complete cure for fibroid with out going for surgery ,i saw people’s testimony on blog sites and Facebook page of how Dr williams prepare herbal cure that shrink there fibroid naturally. i had to try it too and you can,t believe that in just few weeks i started using it all my pains stop gradually . Right now i want to tell you all that i just give birth to a baby boy last month,and on thin now i have not had any pain, and i have just went for text last week and the doctor confirmed that there is no trace of any fibroid in my system . Glory be to God for leading me to this great Dr williams I am so happy as i am sharing this testimony. My advice to you all who thinks that their is no herbal cure for fibroid that is Not true ,just contact him and get cure from his email drwilliams098765@gmail.com and you will be free and free forever, Try it and you will not regret it because it truly works. i hope to see your testimony soon.

    ReplyDelete
  17. ALL THANKS TO DR WILLIAMS WITH HIS HERBAL PORTION I WAS COMPLETELY CURED FROM FIBROID
    I can’t believe this. A great testimony that i must share to all fibroid patient in the world. i never believed that their could be any complete cure for fibroid with out going for surgery ,i saw people’s testimony on blog sites and Facebook page of how Dr williams prepare herbal cure that shrink there fibroid naturally. i had to try it too and you can,t believe that in just few weeks i started using it all my pains stop gradually . Right now i want to tell you all that i just give birth to a baby boy last month,and on thin now i have not had any pain, and i have just went for text last week and the doctor confirmed that there is no trace of any fibroid in my system . Glory be to God for leading me to this great Dr williams I am so happy as i am sharing this testimony. My advice to you all who thinks that their is no herbal cure for fibroid that is Not true ,just contact him and get cure from his email drwilliams098765@gmail.com and you will be free and free forever, Try it and you will not regret it because it truly works. i hope to see your testimony soon.

    ReplyDelete
  18. WE WELCOME YOU ALL TO DEVANSH HERBAL HEALTH CARE.
    We have Quality Rick Simpson Cannabis oil ,fibroid, all types of cancer cure, insomnia,Diabetes,back pain,we also have the herbs that reduces stress and other illness. We are selling our products at very negotiable and workable prices. Apart from our very magnificent prices, when you buy from us, you are assured of the highest quality and purity available in the market,and we are 100% sure of our product, with a guaranteed discreet courier shipping or a special 24 hours confidential overnight delivery of the product to your address. We respect and value your privacy and will dont share your information with anyone. We offer discreet and Reliable packaging and delivery. -Fast and reliable shipment within 24hours within the US and 48 hours internationally, using courier service. Call or Text::::: +1936-2283-155, Email: devanshherbalheathcare@gmail.com for more information

    ReplyDelete
  19. I am Matthias lang, from Orlando u s a, i was diagnosed with FIBROID for 6 years, i lived in pain with the knowledge that i wasn't going to ever give birth, i contacted so many doctors on this issue,and i have use so many western drugs prescribe by various doctors and all was no avail, because i was determined to get my life back, one day i was researching for this on internet and i saw a post about devansh herbal health care who cure different manners of diseases, including fibroid, I contacted them via email: devanshherbalheathcare@gmail.com and made purchase of the fibroid herb, i received the herb through USPS within 24 hours, when i received the herb i applied it as prescribed and i was totally cured of fibroid within 1 months of usages,and to god be the glory i give birth to a baby boy,and on thin now i have never experience any pain in my body again,few days later i went back to my doctor and he confirmed i was completely cured from fibroid, am so happy now, You do not have to suffer more just contact him for his medicine on devanshherbalheathcare@gmail.com.com he will definitely put an end to that problem of yours

    ReplyDelete
  20. I GIVE THANKS TO DR WILLIAMS FOR GIVING ME LIFE.
    He helped me with a fast cure to fibroid,and the size of it was .7cm, Then I started taking the medication for only one month, and now am completely cured from it. I was able to make it without any surgery, now I can live like every normal human and I can eat any food of my choice If you need such help, contact him via mail on drwilliams098765@gmail.com for advice,i hope this also help some one out there.

    ReplyDelete

  21. I GIVE ALL THANKS TO DR WILLIAMS WITH HIS HERBAL PORTION I WAS COMPLETELY CURED FROM FIBROID
    I can’t believe this. A great testimony that i must share to all fibroid patient in the world. i never believed that their could be any complete cure for fibroid with out going for surgery ,i saw people’s testimony on blog sites and Facebook page of how Dr williams prepare herbal cure for diferent king of disease,and with the help of his herb they where able to shrink there fibroid naturally. i had to try it too and you can,t believe that in just few weeks i started using it all my pains stop gradually . Right now i want to tell you all that i just give birth to a baby boy last month,and on thin now i have not had any pain, and i have just went for text last week and the doctor confirmed that there is no trace of any fibroid in my system . Glory be to God for leading me to this great Dr williams I am so happy as i am sharing this testimony. My advice to you all who thinks that their is no herbal cure for fibroid that is Not true ,just contact him and get cure from his email drwilliams098765@gmail.com and you will be free and free forever, Try it and you will not regret it because it truly works. i hope to see your testimony soon.

    ReplyDelete
  22. I GIVE THANKS TO DR WILLIAMS FOR GIVING ME LIFE.
    He helped me with a fast cure to fibroid,and the size of it was .7cm, Then I started taking the medication for only one month, and now am completely cured from it. I was able to make it without any surgery, now I can live like every normal human and I can eat any food of my choice If you need such help, contact him via mail on drwilliams098765@gmail.com for advice,i hope this also help some one out there.

    ReplyDelete
  23. "Dear dr williams, your herb has saved my life and my sanity. I was scared, and had been seeing numerous specialists and almost all of the straight away told me I had to remove my uterus because of my large fibroid. Can you believe this? To top it all up, none of those doctors had answered my simple questions on the subject. I was so scared that I would not be able to have a baby as surgery seemed like the only choice then. Your product had dramatically allayed my fears. I have read many other guides on the subject of fibroids and i think dr williams herb is yours offers and the only true and lasting solution to fibroid. I am a walking living proof of that claim. It has been 3 months since I implemented dr williams herbal portion, and I am now completely clear of fibroids and I am sure I am on my way to become a mother. I also feel very healthy and vibrant. Thank god for your work and support dr williams, for more information about his herb you can contact his email address drwilliams098765@gmail.com

    ReplyDelete
  24. I had a 10 cm fibroid that has shrunk a lot since I gave birth 10 weeks ago (I think I can just feel it at the bottom of my uterus, but luckily you can't ser it.)However, I am still bleeding quite heavily and wonder what I can do about it. I am breastfeeding and my uterus seems to have contracted. i have been suffering from fibroid for long and i have tried so many medications it works a
    little and goes back to how it was before, not until few months back when i saw a post by Sarah about how she got cure with herbal medication from dr.davismartin and got cured. so i email his address and he sent me the herbal product which i use to get rid of my fibroid problem am so happy to be free You can contact him via his email. drdavismartin62@gmail.com

    ReplyDelete
  25. As a sign of gratitude for how my wife was saved from fibroid, i decided to reach out to those still suffering from this.
    My wife suffered from fibroid for more 20 year of marriage after our first born and it was really tough and heartbreaking for me because he was my all and the symptoms were terrible, he had difficulty with his menstrual period and the size of it was 5cm, and he always complain of stomach pain. we tried various therapies prescribed by our neurologist but none could cure her. I searched for a cure and i saw a testimony by someone who was cured and so many other with similar body problem, and he left the contact of the doctor who had the natural cure to fibroid. I never imagined fibroid has a natural cure if not surgery not until i contacted him and he assured me my wife will be fine. I got the herbal medication he recommended and my wife used it as instructed by dr Williams, and in one months time we went to the hospital for scan and the doctor confirmed that there is no trace of fibroid and now she is fully okay, even up till this moment he is so full of life. fibroid has a cure and it is a herbal cure contact the doctor for more info on drwilliams098765@gmail.com on how to get the medication. Thanks for reading my story

    ReplyDelete
  26. I am Shelley from Los Angeles,California, I want to testify on how i got cured from fibroid, I have suffered from fibroid since the 2011 with so mush pain,that i have to spend so mush money getting pain relief in the hospital, and I have visited several doctor ,but all to no avail, my world was gradually coming to an end because of the pin during my menstrual period until i saw a post in a health forum about a herbal Dr Williams who use herbal portion in curing people from different kind of diseases including fibroid, at first i doubted if it we be able to shrink the 9cm large fibroid in my womb, but i decided to give it a try, when i contacted this herbal doctor via his email, he prepared a herbal portion and sent it to me via courier service, when i received this herbal medicine, he gave me step by step instructions on how to apply it, when i applied it as instructed, i was completely free from fibroid just for 1 months of usage,i we recommend this to all my friend family in the world today who still suffering from fibroid you can contact him through his email on drwilliams098675@gmail.com for help.

    ReplyDelete
  27. MY NAME IS NITA.

    Dr Williams,herbal treatment is the best to shrink fibroid naturally.

    Four months ago, I was scheduled an operation to remove a fairly large uterine fibroid (approx. 8 cm), which had caused me a great deal of pelvic pain and pressure on my bladder. My doctor insisted that there was no other choice but to go under the knife and I had reluctantly agreed (after trying several medications to decrease the size of the fibroid to no avail). It was approx. 2 months prior to the surgery when my husband comes across dr williams herbal remedies which my husband found and ordered for me online. With the help of my loving husband, I followed the step and procedure on how i should be taking it. and one months later I was scheduled for an ultrasound check: it was shocking. The fibroid had completely gone, I had consulted my doctor and cancelled the surgery and with your dedicated counseling guidance I managed to completely treat the fibroid from my uterus, along with the pain and anxiety that this condition had inflicted on me. Thank you so much for your kind help,any body with similar problem should contact him on his email address drwilliams098675@gmail.com his a good man

    ReplyDelete