This is a second paper in IFN-lambda series. This new paper published in journal Science provided additional confirmation to the earlier study suggesting the role of commensal microbes in norovirus infection.
The authors showed that antibiotic-treated mice were resistance to chronic intestine norovirus infection.
This resistance to intestine norovirus infection was reversed by normal fecal supplementation implying the role of gut microbes in supporting norovirus infection.
The authors showed that resistance to chronic norovirus infection upon antibiotic treatment were dependent on viral dose and IFN-lambda signaling.
These data suggest that murine norovirus employs endogenous gut microbial flora to establish chronic intestinal infection. It is not clear how microbiota alters IFN-lambda signaling to permit norovirus persistence in the gut.