Showing posts with label antigen. Show all posts
Showing posts with label antigen. Show all posts
Saturday, November 30, 2019

Tracking deletion of autoreactive clones versus Treg generation for thymically expressed epitopes

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So far 3 different outcomes have been identified for developing T cells in the thymus: to develop into naive T cells, get deleted or become...
Saturday, February 9, 2019

An antigen from gut commensal Bacteroides thetaiotaomicron (B. theta) is recognized by Foxp3+ Tregs

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1. B.theta-specific T cells when transferred into #antibiotic -treated and B.theta #colonized T cell-deficient mice ( #RAG1 -KO) develop ...
Wednesday, January 16, 2019

Foxp3+ Tregs suppress other T cells by stripping DCs of specific antigen/MHC complexes

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Ag-specific or not Ag-specific, that is [maybe was] question for #Foxp3 + Tregs mechanism of action. New paper in @NatImmunol from #Shevach...
Sunday, October 14, 2018

New auto[cross-reactive]-antigen, GDP-l-fucose synthase, identified in MS patients

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Multiple sclerosis  (MS) is a debilitating autoimmune disease affecting nervous system. Several auto-antigens have been traditionally suspe...
Wednesday, December 27, 2017

Effort to identify tumor-specific antigens: The University Industrial Complex study results

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New study in journal Cell is prime example why utilization of sophisticated high-throughput methods and computer technologies does not gua...
Wednesday, July 26, 2017

IBD converts tolerant antigens into immunogenic

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Inflammatory bowel disease (IBD) is a pathological condition wherein body's immune cells wrongly attack its own or commensal microbiota...
Sunday, July 16, 2017

Identification of prostate-antigen specific natural Tregs (in mice)

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Foxp3+ Tregs are central player in maintaining tolerance to self and other environmental antigens. However, till to this date we know litt...
Thursday, June 2, 2016

Combination of checkpoint inhibitor and IL-21-primed melanoma-specific T cells produced durable response, "cure", in melanoma patient

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This week Journal of Experimental Medicine published a  case study of a single melanoma patient who achieved durable response (>5 years...
Wednesday, November 18, 2015

Time dictates tolerance to skin microbiota

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Yesterday journal Immunity published a very interesting study showing that early wave of thymic Foxp3- positive  T cells specifically popu...
Saturday, April 11, 2015

Anergic B cells respond to polyvalent antigens via IgD receptor

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Naive B cells express IgM and IgD receptors. Both receptors share the same unique immunoglobulin variable region but differ in immunoglobu...