A new paper in @CellCellPress from Bacher/Scheffold lab showed that IL-17+ T cell response to airborne #fungus such as #Aspergillus fumigatus found in individuals with #asthma,#COPD, and CF,are in fact expanded by gut commensal pathobiont #Candida #albicans via #crossreactivity.— David Usharauli (@3DiMMUNE) February 23, 2019
1. majority of IL-17+ #Tcells found in healthy donors are specific C. albicans. #Immunology #TH17 #fungi pic.twitter.com/3WITidrcCn— David Usharauli (@3DiMMUNE) February 23, 2019
3. In fact, when C. albicans-specific T cells were depleted from #Aspergillus fumigatus-specific T cell pool IL-17 response was gone too suggesting that most if not all of IL-17+ T cells specific for A. fumigatus were indeed #crossreactive to C. albicans. pic.twitter.com/cZEu50Uwep— David Usharauli (@3DiMMUNE) February 23, 2019
5. similar expansion of Aspergillus fumigatus-specific T cells producing IL-17 were observed in individuals with #crohnsdisease too. pic.twitter.com/L0VbmCcFj5— David Usharauli (@3DiMMUNE) February 23, 2019
As both #fungi are naturally available in the environment any #immunopathology driven by excess of IL-17 response must be the result of some other changes in the host that makes it susceptible to pathology. what???— David Usharauli (@3DiMMUNE) February 23, 2019
